https://derekwang2002.github.io/ai-intelligence/projects/rfd4-proteina/ AI 模型、Agent、工程与基础设施的重要变化，附一手来源与建议等级。 zh-CN Mon, 02 Nov 2026 16:56:00 GMT https://derekwang2002.github.io/ai-intelligence/events/ev-20261021-06/ ev-20261021-06-published Wed, 21 Oct 2026 15:58:23 GMT 新事件 TRIAL <p>NVIDIA 与 RosettaCommons 以 BSD-3-Clause 发布 RFD4-Proteina 代码和免申请权重。约 4.35 亿参数的模型联合设计蛋白质序列与全原子结构，reward-guided inference-time search 会从得分更高的中间候选继续分支。公开产物可以复现，但质量与 1.37–1.73 倍 BioIR 加速仍是发布方结果。</p><p><strong>为什么读：</strong>RFD4-Proteina 公开代码、权重与测试数据，让蛋白质联合设计方法可以立即复现。</p><p>建议等级：TRIAL</p><p>来源：<a href="https://developer.nvidia.com/blog/design-proteins-with-rfd4-proteina-using-reward-guided-inference-time-search/">RFD4-Proteina technical release</a> · <a href="https://github.com/RosettaCommons/RFD4-Proteina">RFD4-Proteina repository</a> · <a href="https://huggingface.co/nvidia/RFD4-Proteina">RFD4-Proteina weights</a></p>